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IgG4 Increases with Repeated mRNA Vaccines: Linked to Disease

A peer-reviewed study entitled “IgG4 Antibodies Induced by Repeated Vaccination May Generate Immune Tolerance to the SARS-CoV-2 Spike Protein” reports, “recent investigations have found abnormally high levels of IgG4 in people who were administered two or more injections of the mRNA vaccines.” The paper states, “compelling evidence shows that among COVID-19 vaccines, only the mRNA vaccines (but not the adenoviral vector-based vaccine from AstraZeneca) induced a remarkable increase in IgG4 levels.”

The paper was published on May 17, 2023, in a special issue entitled “SARS-CoV-2: Immune Tolerance and Autoimmune Diseases after COVID-19 Vaccination and Its Related Adverse Events” of the Vaccines Journal featured in the “COVID-19 Vaccines and Vaccination” section of the Journal featuring 1397 papers on all facets of the COVID-19 vaccines and their administration.

Dr. Mikolaj Raszek, Founder and managing director of Merogenomics Inc., provides an excellent summary explanation of the findings below:

The paper’s findings are worrisome because it shows evidence that repeated mRNA vaccinations can cause disease due to increased IgG4 levels. According to the paper, “Increased IgG4 synthesis due to repeated mRNA vaccination with high antigen concentrations may also cause autoimmune diseases and promote cancer growth and autoimmune myocarditis in susceptible individuals.”

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